Week 10 – Bills DBs vs. Cardinals WRs/Dawson Knox vs Isaiah Simmons
In Week 10 against the Arizona Cardinals, the obvious player matchups to watch are between the corners and receivers on both sides. After acquiring DeAndre Hopkins in a trade with the Houston Texans this offseason, the Cardinals now have a deep receiving group led by Larry Fitzgerald, Hopkins and rounded out by Christian Kirk in the slot. Behind these three, the Cardinals still have a trio of sophomore receivers in Andy Isabella, KeeSean Johnson, and Hakeem Butler, who missed his entire rookie season due to injury.
With that said, the Bills could have a tough time matching up against the Cardinals in 00 personnel, which includes five receivers on the field at once.
As for the other side of the ball, the Buffalo Bills will be squaring off against former teammate Jordan Phillips, and the highest paid center in the league, Mitch Morse, will be faced with the task to neutralize his penetration into the backfield. Additionally, the Bills will have to gameplay for the most versatile prospect out of the 2020 NFL Draft in Isaiah Simmons. He is capable of playing as an off-ball linebacker, edge rusher, safety, and nickel corner; but expect him to be matched up against Dawson Knox a whole lot in this contest.