Buffalo Bills: Key matchups to look forward to in each game in 2020

ORCHARD PARK, NY - DECEMBER 29: Josh Allen #17 of the Buffalo Bills shakes hands with Sam Darnold #14 of the New York Jets after the game at New Era Field on December 29, 2019 in Orchard Park, New York. New York defeats Buffalo 13-6. (Photo by Brett Carlsen/Getty Images)
ORCHARD PARK, NY - DECEMBER 29: Josh Allen #17 of the Buffalo Bills shakes hands with Sam Darnold #14 of the New York Jets after the game at New Era Field on December 29, 2019 in Orchard Park, New York. New York defeats Buffalo 13-6. (Photo by Brett Carlsen/Getty Images) /
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MIAMI, FL – NOVEMBER 17: Dawson Knox #88 of the Buffalo Bills runs after making on catch on his way to scoring a touchdown in the third quarter against the Miami Dolphins at Hard Rock Stadium on November 17, 2019 in Miami, Florida. (Photo by Eric Espada/Getty Images)
MIAMI, FL – NOVEMBER 17: Dawson Knox #88 of the Buffalo Bills runs after making on catch on his way to scoring a touchdown in the third quarter against the Miami Dolphins at Hard Rock Stadium on November 17, 2019 in Miami, Florida. (Photo by Eric Espada/Getty Images) /

Week 10 – Bills DBs vs. Cardinals WRs/Dawson Knox vs Isaiah Simmons

In Week 10 against the Arizona Cardinals, the obvious player matchups to watch are between the corners and receivers on both sides. After acquiring DeAndre Hopkins in a trade with the Houston Texans this offseason, the Cardinals now have a deep receiving group led by Larry Fitzgerald, Hopkins and rounded out by Christian Kirk in the slot. Behind these three, the Cardinals still have a trio of sophomore receivers in Andy Isabella, KeeSean Johnson, and Hakeem Butler, who missed his entire rookie season due to injury.

With that said, the Bills could have a tough time matching up against the Cardinals in 00 personnel, which includes five receivers on the field at once.

As for the other side of the ball, the Buffalo Bills will be squaring off against former teammate Jordan Phillips, and the highest paid center in the league, Mitch Morse, will be faced with the task to neutralize his penetration into the backfield. Additionally, the Bills will have to gameplay for the most versatile prospect out of the 2020 NFL Draft in Isaiah Simmons. He is capable of playing as an off-ball linebacker, edge rusher, safety, and nickel corner; but expect him to be matched up against Dawson Knox a whole lot in this contest.