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Buffalo Bills: Game-by-game predictions for the 2021 season

By Brandon Croce

ORCHARD PARK, NEW YORK - DECEMBER 13: Buffalo Bills offense lines up against the Pittsburgh Steelers defense during the fourth quarter at Bills Stadium on December 13, 2020 in Orchard Park, New York. (Photo by Bryan Bennett/Getty Images)
ORCHARD PARK, NEW YORK - DECEMBER 13: Buffalo Bills offense lines up against the Pittsburgh Steelers defense during the fourth quarter at Bills Stadium on December 13, 2020 in Orchard Park, New York. (Photo by Bryan Bennett/Getty Images) /
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Bills linebacker Tremaine Edmunds fills a hole as Chiefs running back Clyde Edwards-Helaire looks for running room.Jg 101920 Bills 10 /

Week 4: Houston Texans at Buffalo Bills

The Houston Texans have been one of the top teams in the AFC over the past few seasons but struggled to maintain that success last year. They now enter this season with a new head coach and serious questions at quarterback about whether Deshaun Watson will be under center for them this year.

This is a game that certainly has the potential to be a trap game with the defending AFC Champions the following week on primetime but playing in front of the home crowd keeps them focused and they move to 4-0 on the season.

Prediction: Win (4-0)

Week 5: Buffalo Bills at Kansas City Chiefs (Sunday Night Football)

This is without a doubt one of the top games on the Buffalo Bills schedule. One of the biggest storylines this season will be whether or not the Bills have closed the gap to surpass the Kansas City Chiefs as the top team in the conference.

They are going to get that answer very early on as they will face the Chiefs in primetime on Sunday Night Football. This is certainly going to be a tough challenge for the Bills going on the road against a very good Chiefs team. While it should be close, this is likely the first game the team loses this season.

Prediction: Loss (4-1)

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