Buffalo Bills at Carolina Panthers: Three Keys to the Game

ORCHARD PARK, NY - AUGUST 31: Greg Mabin
ORCHARD PARK, NY - AUGUST 31: Greg Mabin /
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ORCHARD PARK, NY – SEPTEMBER 10: head coach Sean McDermott of the Buffalo Bills walks off the field after defeating the New York Jets 21-12 on September 10, 2017 at New Era Field in Orchard Park, New York. (Photo by Brett Carlsen/Getty Images)
ORCHARD PARK, NY – SEPTEMBER 10: head coach Sean McDermott of the Buffalo Bills walks off the field after defeating the New York Jets 21-12 on September 10, 2017 at New Era Field in Orchard Park, New York. (Photo by Brett Carlsen/Getty Images) /

Prediction: Bills 24, Panthers 21

Buffalo isn’t getting nearly enough credit as touchdown underdogs.

The Bills have a clear advantage with McDermott as their head coach. He knows both the Carolina offense and defense like the back of his hand. That’s valuable.

Not to mention Joe Webb was on the Panthers a few weeks ago and Mike Tolbert was on the team last season.

"“It’s not about what everybody else is doing, it’s about what we do,” Tolbert said. “We know that Carolina is a good football team, obviously, but we also know what we can exploit and we know what we have to do to beat them. It’s not about a big return home or this or that, it’s about going out at 1:00 on Sunday and getting a win.”"

LeSean McCoy proved why he’s one of the best backs in the league and he’s primed for another big game.

Next: Buffalo Bills vs. Carolina Panthers: Vegas Line, Weather, Predictions

If Buffalo can take away Newton’s running ability and McCaffey, they’ll be on there way to another week in first place.