James Cook has been off to another great start in 2025. The Bills' running back is tied for the NFL league lead with four touchdowns in three games, and the next team he'll take on is the New Orleans Saints.
How will Cook fare in Week 4? Let's check out his previous Week 4 performances to see how he's done, per StatMuse.
Cook has struggled in three Week 4 games in his career. He's averaged 22.7 rushing yards and has scored just one touchdown total in Week 4. However, that's counting a 2022 Week 4 game when Cook, a rookie, did not get a single carried and was targeted just once.
His best Week 4 game was in 2023, when Cook rushed for 29 yards and a touchdown on 12 attempts, while also securing a 48-yard reception.
This year, he's taking on the Saints in Week 4. Cook has never played the Saints in his career, so it will be interesting to see how he fares against a usually solid New Orleans defense.
How will James Cook perform in Week 4?
So far in 2025, the Saints are allowing 103.3 rushing yards per game. They've played the 49ers, Cardinals, and Seahawks, three NFC West teams with solid running backs. New Orleans has allowed two rushing touchdowns this season, both coming at the hands of Seattle running back Kenneth Walker.
The Saints are only allowing 3.6 yards-per-carry, which is the sixth-best mark in the NFL. Cook, on the other hand, is averaging 5.4 yards-per-attempt, which is among the best marks in the league so far.
The prediction for Cook this week? He gets the better of New Orleans. He'll have a slow first half, but as Josh Allen and the passing attack open up the offense, Cook will begin to find holes. He'll finish the game with 85 rushing yards on 18 carries, averaging 4.7 yards per attempt. He'll also score a touchdown, helping the Bills win 34-20 over the Saints.