1. Defensive Tackle
This is my number one position that the Bills need to seriously look to upgrade now if they want to help this defense this season. We know the Bills like to rotate their defensive line and adding another solid defensive tackle to go with Ed Oliver this season and DaQuan Jones (maybe late this season) and into next season, would be huge for this defense.
In my recent trade targets article, I tabbed the Carolina Panthers, Derrick Brown as an option. He's a massive human being who could be instantly plugged in the middle and help not only the edge rushers but also the linebackers, particularly Dorian Williams. There are other options of course, but Brown is the one I would try to acquire, and his contract is one the Bills could work with as well.