4. San Francisco 49ers (Home)
In their first meeting since 2020, the 49ers will travel to Buffalo for a meeting with the Bills. After failing to win the Super Bowl last season, the 49ers are expected to be contenders once again — and the Bills will be treating this game as a litmus test.
In order to be the best, you've gotta beat the best, and the 49ers have won the NFC twice in the past five seasons.
Depending on when this game is played, the 49ers won't be getting a warm welcome from the Buffalo climate or the fans. When any contender that plays in warm weather comes to Buffalo late in the season, it feels like Bills Mafia's best chance to show what they're made of.
Expect this meeting between two ubertalented rosters to be loud.
3. Baltimore Ravens (Away)
In a matchup with last year's number one seed in the AFC, the Bills travel to Baltimore for a clash against two-time MVP Lamar Jackson who — if you ask Bills fans — robbed Allen of his first MVP in 2023.
Allen scored 15 more touchdowns than Jackson last season, but the Ravens' 13-3 record and Jackson's lack of interceptions were enough to push him over the edge.
In the offseason, the Ravens added former Tennessee Titans running back Derrick Henry who has scored seven touchdowns in his last four games against the Bills. The combination of Jackson and Henry will give opposing defense some serious fits, including the Bills.
In this game, Allen gets a chance to remind the world that he's better than the Ravens signal caller. And perhaps more importantly, gain the Bills some ground in the AFC playoff standings.