Jaguars vs. Bills prediction, odds, spread, injuries, trends for NFL Week 5

Can the Bills cover the spread for the fourth straight game?

Buffalo Bills quarterback Josh Allen.
Buffalo Bills quarterback Josh Allen. / Gregory Fisher-USA TODAY Sports
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For the second straight week, the Jacksonville Jaguars will have an early start in London. 

Last week, the team defeated the Atlanta Falcons, but it has a much tougher task against the 3-1 Buffalo Bills in Week 5.

Buffalo has won three straight games by 28 or more points, absolutely dominating the Miami Dolphins in Week 4 to take control of the AFC East lead. The Bills are also getting some terrific play from Josh Allen, who is now the consensus favorite to win the league's MVP award. 

The Jaguars have gotten off to a slow start, losing two early games before getting back to .500 in Week 4. Can Trevor Lawrence and company pull off the upset across the pond? 

For more Week 5 picks, check out BetSided's NFL betting analyst Iain MacMillan’s best bet for every game on the slate here!

Oddsmakers don’t seem to think so, setting the Bills as a 5.5-point favorite.  

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Jaguars vs. Bills odds, spread and total for NFL Week 5

Jaguars vs. Bills betting trends

  • The OVER is 2-2 in the Jaguars’ four games.
  • The OVER is 2-2 in the Bills’ four games.
  • Buffalo is 3-1 against the spread this season.
  • The Jaguars are 2-2 against the spread this season.

Jaguars vs. Bills injury reports

Jacksonville Jaguars injury report

  • Devin Lloyd – out
  • Parker Washington – doubtful
  • Jamal Agnew – questionable
  • Zay Jones – questionable
  • Antonio Johnson – questionable

Buffalo Bills injury report 

  • Jordan Poyer – questionable
  • Christian Benford – questionable
  • Khalil Shakir – questionable
  • Tre’Davious White – out
  • Von Miller – questionable (PUP)

Jaguars vs. Bills how to watch

  • Date: Sunday, Oct. 8
  • Game Time: 9:30 a.m. EST
  • Venue: Northumberland Development Project
  • How to Watch (TV): NFL Network
  • Jacksonville Jaguars Record: 2-2
  • Buffalo Bills Record: 3-1

Jaguars vs. Bills key players to watch

Jacksonville Jaguars

Trevor Lawrence: It hasn’t been a great start to the season for Trevor Lawrence, as he has been one of the worst quarterbacks in terms of EPA/Play this season.

This is a moment for him to show he can compete with one of the game’s best in Allen. 

Buffalo Bills 

Josh Allen: The MVP favorite, Allen had five total touchdowns in Week 4 and is looking to build on that against an average Jacksonville defense. A strong showing would further him as the favorite for MVP. 

Von Miller (if he plays): Miller started this season on the PUP list, but he is resuming practicing. If he plays, he’d be a massive boost to this Buffalo pass rush. 

Jaguars vs. Bills prediction and pick

This is one of the better matchups in Week 5, but I still think the Bills can win this game going away. 

Buffalo has been dominant the last few weeks, and the Jaguars haven’t really gotten things going on offense – needing a defensive touchdown to pull away from Atlanta last week. 

Since losing in Week 1, Buffalo has easily covered the spread in three straight games, winning those games by a combined 90 points. 

I am a little concerned about Buffalo’s league-worst run defense, but it held Raheem Mostert to just nine yards on seven carries in Week 3. Those numbers may be a little inflated by a 55-yard run from De’Von Achane that pushed him over 100 yards on the day. 

After watching Jacksonville struggle to score the first four weeks, I think the Bills are the right bet in this game. 


Odds refresh periodically and are subject to change.

Find Peter Dewey's betting record here.