Giants vs. Bills Week 6 Opening Odds Point to Huge Blowout 

Buffalo is expected to be two touchdowns better than New York this week

The Bills are the biggest favorites on the board in Week 6 and I bet you’re not surprised. 

New York has been downright horrendous this season and injuries to Daniel Jones and Saquon Barkley have complicated things even further. 

Typically a 14-point spread would be difficult to cover in the NFL? But maybe not in this spot.

Let’s see if we can talk ourselves into backing Buffalo to cover a massive point spread.

Giants vs. Bills Week 6 Opening Odds

Buffalo’s moneyline odds (-900) are hardly worth mentioning except to point out how likely it is that it wins this week. 

The Bills were double-digit favorites seven times last season. They only went 2-5 against the spread in those games, but one of those was a 14-point spread against a hapless Steelers squad (Final score: 38-3).

This seems to be a similar situation. 

New York could have both Jones and Barkley available this week, but both are coming off injuries and this team has been terrible in the first half of games even when they were both on the field. 

The Giants have scored 19 total points across five first halves this season. If they get off to a sluggish start like that, it’s going to be a challenge for them to cut into the deficit – especially when you consider they are dead last in the NFL with just 4 yards per play. 

Of course, there’s also the fact that New York is allowing the most sacks in the NFL (6 per game) and Buffalo is leading the NFL in sacks per game (4.2). 

That doesn’t sound like a great matchup for the Giants. 

Another bet to target in this game could be Under 45 total points. The under has hit in four of five Giants games this season and 3-of-5 times in Buffalo games. 

You can take the sweat out of backing a Buffalo blowout this week if you sign up with Caesars Sportsbook, use our promo code FSNFL1000 and deposit $10 or more. 

Then, your first bet at Caesars will be backed by the house for up to $1,000! If you lose, you'll get the funds back as bonus bets to try again with no questions asked. Sign up now!

Game odds refresh periodically and are subject to change.