Giants vs. Bills prediction, odds, spread, injuries, trends for NFL Week 6

A full betting preview for the NFL Week 6 edition of Sunday Night Football between the Giants and Bills.
Oct 8, 2023; London, United Kingdom;  Buffalo Bills quarterback Josh Allen (17) during the first
Oct 8, 2023; London, United Kingdom; Buffalo Bills quarterback Josh Allen (17) during the first / Peter van den Berg-USA TODAY Sports
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The Buffalo Bills are returning from their trip to London with an additional loss on their record after falling to the Jacksonville Jaguars in Week 5.

Luckily for them, they not get to take on arguably the worst team in the NFL in the New York Giants.

Sure, they should win, that's basically a foregone conclusion in this spot, but covering the spread is a whole different question so that's what we're going to talk about in this article.

If you want the rest of my picks for every NFL Week 6 game, check out the latest edition of the "Road to 272 Bets."

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Giants vs. Bills odds, spread, and total

Giants vs. Bills betting trends

  • Giants are 0-6 ATS in their last six games
  • The UNDER is 5-1 in the Giants' last six games
  • Giants are 6-2-1 ATS in their last nine games vs. Bills
  • The UNDER is 13-2 in the Giants' last 15 games against AFC opponents
  • Bills are 6-1 ATS in their last seven games vs. NFC East opponents
  • The UNDER is 6-1 in the Bills' last seven games played in October

Giants vs. Bills injury reports

New York Giants injury report

  • Marcus McKethan - G - Questionable
  • Micah McFadden - LB - Questionable
  • Shane Lemieux - G - Questionable
  • Andrew Thomas - OT - Questionable
  • Daniel Jones - QB - Questionable

Buffalo Bills injury report

  • Dalton Kincaid - TE - Questionable
  • DaQuan Jones - DT - Out
  • Christian Benford - CB - Questionable
  • Shaq Lawson - DE - Questionable
  • Greg Rousseau - DE - Questionable

Giants vs. Bills how to watch

  • Date: Sunday, Oct. 15
  • Game Time: 8:20 p.m. EST
  • Venue: Highmark Stadium
  • How to Watch (TV): NBC
  • New York Giants Record: 1-4
  • Buffalo Bills Record: 3-2

Giants vs. Bills key players to watch

New York Giants

Parris Campbell: If the Giants want to rebound and gain some level of momentum this season, they need their receivers to step up. Parris Campbell has quietly played some solid football, and it second on the team in receptions with 16. If he can get some more YAC, he could be a key part of the Giants offense moving forward.

Buffalo Bills

Tarrel Bernard: With Matt Milano and other key defensive players injured, Tarrel Bernard needs to step up in a big way. He already leads the team in tackles with 45 and has two sacks as well, but he needs to keep playing at a high-level so the rest of the defense can rally around him.

Giants vs. Bills prediction and pick

The New York Giants are a bad football. There's no other way to put it. They're dead last in several key metrics including net yards per play with a mark of -2.3. That's -0.9 yards worse than the next worst team. It's a crying shame that we have to watch this team play in a primetime game for the fourth time this season.

We shouldn't be afraid to bet on the Bills to cover this big number. Even though they have two losses on the season, they have an average scoring margin of +15.8. When they win, they regularly win big.

Let's back the Bills to win and cover on Sunday Night Football.


Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!