Stefon Diggs
Diggs hasn't been a huge factor in the offense since Week 12 against the Eagles, other than that, he hasn't been that dominant number-one option on the offense. This could be due to the change in scheme with Joe Brady as OC, but there were a good amount of drops that Diggs had that were very uncharacteristic.
Diggs is still a very talented receiver, but the Bills will need to utilize him going forward, especially against a weak Patriots secondary. Re-establishing that chemistry between Diggs and Allen will help the Bills in future games (assuming they can make the postseason). Diggs hasn't finally recorded a 100-yard game since Week 6, and involving him in the game plan this week will be crucial in dominating this Patriots team.
James Cook
Being two-dimensional is crucial in any NFL game, and that wouldn't be possible for the Bills offense unless they get James Cook going. Cook still had 20 attempts but only recorded 70 yards while also fumbling the ball in the fourth quarter to help give the Chargers the lead.
Cook was great in his four-game stretch since Joe Brady took over, but ended up having an off game. Cook is still a very dangerous back and will be dangerous down the stretch, so expect him to have an impact against the Patriots and get right back to cooking.