Ed Oliver
The Chiefs' offense has run the ball very successfully this year with their star runningback Isiah Pacheco, a very hard runner who's having a great year and just recently coming off a 100-yard rushing game. The Chiefs' interior offensive line is also one of the best in the league in terms of overall blocking, especially run blocking with Creed Humphrey and Joe Thuney being the best in that interior.
Oliver needs to find ways to disrupt that interior on running plays and try and disrupt their entire scheme. Oliver has been a staple on the interior all season, recording 11 TFLs and always finding his way in the backfield.
Oliver has also been very effective in pass-rush situations, as he has recorded six sacks so far, five quarterback knockdowns, and leads the league in pressures for defensive tackles. Oliver needs to showcase this against the Chiefs, especially with Mahomes under center, and give the Bills a better chance of winning the matchup.