Bills vs. Commanders prediction, odds, spread, injuries, trends for NFL Week 3

Can Buffalo hand Washington its first loss of the season?

Bills quarterback Josh Allen celebrates a touchdown in a 38-10 win over the Raiders.
Bills quarterback Josh Allen celebrates a touchdown in a 38-10 win over the Raiders. / Jamie Germano / USA TODAY NETWORK

The Buffalo Bills bounced back in a big way in Week 2, dominating the Las Vegas Raiders to move to 1-1 on the season.

Now, they take on the Washington Commanders in Week 3, a team that BetSided’s Iain MacMillan believes is one of the most fraudulent squads in the NFL. 

Sure, Washington has won both of its games, but the team beat two bad teams in the Arizona Cardinals and Denver Broncos by a combined six points. Things are going to get much tougher with Josh Allen and company coming to town in Week 3.

For more Week 3 picks, check out BetSided NFL betting analyst Iain MacMillan’s best bet for every game on the slate here!

This is an important game for Buffalo in the AFC East division race, and the team is favored by 6.5 points on Sunday. Does Sean McDermott’s team cover the spread in this matchup? 

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Bills vs. Commanders odds, spread and total

Bills vs. Commanders betting trends

  • The Bills are 1-1 against the spread this season
  • The Commanders are 1-1 against the spread this season
  • Washington is 1-0 against the spread as an underdog in 2023
  • The OVER is 1-1 in both teams four games this season

Bills vs. Commanders injury reports

Buffalo Bills injury report

  • Micah Hyde – questionable 
  • Leonard Floyd – questionable
  • Von Miller – out

Washington Commanders injury report

  • Jartavius Martin – questionable
  • Logan Thomas – questionable

Bills vs. Commanders how to watch

  • Date: Sunday, Sept. 24
  • Game Time: 1:00 p.m.
  • Venue: FedEx Field
  • How to Watch (TV): CBS
  • Bills Record: 1-1
  • Commanders Record: 2-0

Bills vs. Commanders key players to watch

Buffalo Bills

Dalton Kincaid: The 2023 first-round pick is on the verge of breaking out, catching nine passes through his first two NFL games. Kincaid didn’t find the end zone in Week 2, but he’s clearly more involved in the offense than Dawson Knox at the moment. 

Josh Allen: The Bills need Allen to play turnover-free football in a road game after he threw eight picks in eight road games during the 2022 season. He was much better in Week 2, which is a good sign for the Bills going forward. 

Washington Commanders

Sam Howell: The second-year quarterback has looked solid against Denver and Arizona, but how will he handle the Buffalo defense? Howell and the Commanders may have a tough time if the team needs to lean on his arm to win. 

Bills vs. Commanders prediction and pick

I don’t know if I’m willing to go as far as to say that the Commanders are frauds, but they haven’t exactly blown me away in these first two weeks. 

Offensive coordinator Eric Bieniemy is certainly getting a ton out of this offense, but I question the defense’s ability to slow down the Bills after giving up 33 points to Denver in Week 2. 

Also, Washington is just 23rd in the NFL in yards per play on offense, and it struggled to put away the Cardinals at home in Week 1. The Bills are a far superior team, and they won’t give Washington nearly as many chances to hang around. 

I think Allen and the Bills are on a mission after disappointing Week 1 loss – which sort of served as a wake-up call. 

I like the Bills to get things done on the road in Week 3.

Game odds refresh periodically and are subject to change.

Find Peter Dewey's betting record here.