Buffalo Bills Career Sacks (171 sacks) and Most Sacks in a Season (19 sacks)
Record Holder: Bruce Smith
The final two records are owned by the same player in Bruce Smith, who was a cornerstone of the Buffalo Bills defense for 15 seasons after being selected first overall in the 1985 NFL Draft. In his career, he has 200 sacks which is an NFL record for most career sacks, with 171 of those sacks coming in a Bills uniform, which is the franchise record for career sacks.
Bruce Smith was an elite pass rusher with double digit sacks in 12 of his 15 seasons with the Bills, including a record 19 sacks in 1990 when he would be named Defensive Player of the Year and finish fourth in the MVP voting.
The one player who probably has the best chance currently on the roster to break both records is Greg Rousseau, who was the Bills' first round pick in the 2021 NFL Draft. However, both seem unlikely at this point.
The reason the season record is unlikely is that the Buffalo Bills like to rotate their defensive ends and they usually don't play more than 50% of the snaps. This would limit Rousseau's chances of reaching that number but having 17 regular season games certainly helps his chances.
As for the career record, again Rousseau is probably the most likely candidate presently but he has only 12 career sacks in his first two years. It wouldn't be surprising to see Rousseau develop into a 12-15 sack player as early as this season. However, can he do that for the next 10-15 years? That seems much more of a longshot and why both records for Bruce Smith seem safe at this time.