5 initial reactions from Buffalo Bills game against the Jacksonville Jaguars

Injuries were an issue and could derail this season yet again

The loss of Matt Milano was a massive hit to the Bills' defense. From what I saw, with the cast and being carted to the locker room, appears the injury is significant, and he could be out for a while. Last week it was Tre'Davious White and now Milano. Let's hope it ends there and history isn't repeating itself.

When targeted by opposing quarterbacks this season, Milano was allowing a QB rating of only 56.9. He's recorded two interceptions and 11 total stops. It's safe to say that Milano is the heartbeat of the Buffalo Bills defense. Now it's up to the rookie Dorian Williams to step up and fill his shoes.