The Buffalo Bills coaching staff won't ask Rasul Douglas to do it alone and they are likely to give him plenty of help over the top. This will be a key week for Micah Hyde as well, who does a great job playing that deep safety and ensuring there aren't big plays over the top.
Hyde has dealt with injuries a few times this season and just returned last week against the Patriots after missing two games due to a neck stinger. In that game he would have his first pass defended since Week 9 against the Bengals.
The last time he had an interception though was much longer and in fact, was back in Week 4 in the Bills' first matchup with the Dolphins. It came at a key point in the game as the Bills were holding onto a 34-20 lead and Hyde would intercept a deep throw by Tua Tagovailoa to Robbie Chosen. The Bills would end up scoring a touchdown after that turnover and the Dolphins never really got back into the game.
I would expect the Buffalo Bills to keep Micah Hyde deep to defend those big plays and he has a chance to make an impact in this role.