Shut down the Steelers run game (specifically Najee Harris)
While Mason Rudolph has looked great for the Steelers offense, the bigger storyline might be the return of Najee Harris being a dominant running back. In the first 14 games this season, Harris averaged only 51.6 rushing yards per game and four rushing touchdowns.
However, in the last three games he has averaged 104 rushing yards per game and has four total touchdowns in this final stretch of the regular season. He has been a big part of the Steelers offense with 19 or more rushing attempts in each of these games after having 19 or more in 1 of the first 14 games.
The Steelers have done a good job of finding a balance of grinding defenses with the run and it opens up those big plays through the air. The Bills are going to need to be prepared to shut down both.