San Francisco 49ers
The San Francisco 49ers made the biggest trade of the season so far by acquiring running back Christian McCaffrey from the Carolina Panthers. While it remains to be seen just how much he might play with limited practice time with his new team, this is a big game for the San Francisco 49ers.
And Buffalo Bills fans should be rooting for the 49ers this week as they play the team the Bills just beat last week in the Kansas City Chiefs. While the Bills did win and do hold the tiebreaker, Kansas City is probably the best team currently in the league after Buffalo.
The Chiefs are going to likely be in the discussion for that top seed all year so another game in the loss column would go a long way in giving the Buffalo Bills a little breathing room.