Final 2022 regular season win-loss predictions for the Buffalo Bills

Week 6: Buffalo Bills at Kansas City Chiefs

The Buffalo Bills have their bye week in Week 7 but before they get a week off they head into arguably the most marquee matchup of the regular season. In Week 6, they travel to Kansas City to face the Chiefs, the team that has ended their season each of the last two years.

While this will be the fifth time the Buffalo Bills have played the Chiefs since 2020, this seems like a very different team. While most of the core players are still intact, like Patrick Mahomes and Travis Kelce, they lost a number of starters this offseason like Tyreek Hill and Tyrann Mathieu.

The Chiefs this year look to be relying more on rookies than in years past as players like Trent McDuffie and George Karlaftis will have prominent roles on defense.

Similar to the regular season last year, the Buffalo Bills wanted to get a win to put the prior year’s playoff loss behind them. That should be the same sentiment this year and I believe they do that with another regular season win in Kansas City.

Prediction: Win (4-2)