5 toughest games on the Buffalo Bills schedule in the 2022 season

Week 6: Buffalo Bills at Kansas City Chiefs

This game shouldn’t be a surprise as this Week 6 matchup with the Kansas City Chiefs will be the most talked-about matchup and one of the best games on the regular season schedule for the NFL but also one of the toughest games for the Buffalo Bills.

This will be the fifth time the Buffalo Bills will play the Chiefs over the past three seasons and will be the fourth trip to Arrowhead Stadium over that stretch. While the Bills did get the win during their regular season matchup last year, they have lost two times when it has mattered the most, once in the AFC Championship Game in 2020 and last year in the AFC Divisional Round.

This Chiefs team doesn’t look as imposing as some of the teams from the past with Tyreek Hill and Tyrann Mathieu no longer with the franchise. However, as long as they have Patrick Mahomes under center and Andy Reid on the sideline, this is a team that can’t be taken lightly and is going to be one of the toughest games on the schedule.