
Week 13 – Away vs San Francisco 49ers
That brings us to the hardest matchup on the 2020 slate, a trip out west to take on the defending NFC Conference Champions. This primetime matchup could be the lowest scoring game of the season as the top defenses in the league square off.
While the Bills offense line improved in 2019 this 49ers defense should give them problems all game. How many times have we seen the Bills defense win a game for them, well, this feels like another game that the defense might have to get a huge play late in the fourth quarter if the Bills want to head home with a win.
Winning this game will have the Buffalo Bills feeling like a Super Bowl run is in their future for the remaining of the season.