Buffalo Bills: Game-by-game predictions for the 2020 season

HOUSTON, TEXAS - JANUARY 04: Josh Allen #17 of the Buffalo Bills signals to his team against the Houston Texans during the first quarter of the AFC Wild Card Playoff game at NRG Stadium on January 04, 2020 in Houston, Texas. (Photo by Christian Petersen/Getty Images)
HOUSTON, TEXAS - JANUARY 04: Josh Allen #17 of the Buffalo Bills signals to his team against the Houston Texans during the first quarter of the AFC Wild Card Playoff game at NRG Stadium on January 04, 2020 in Houston, Texas. (Photo by Christian Petersen/Getty Images) /
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SANTA CLARA, CALIFORNIA – JANUARY 19: Nick Bosa #97 of the San Francisco 49ers runs onto the field prior to the start of the NFC Championship game against the Green Bay Packers at Levi’s Stadium on January 19, 2020 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)
SANTA CLARA, CALIFORNIA – JANUARY 19: Nick Bosa #97 of the San Francisco 49ers runs onto the field prior to the start of the NFC Championship game against the Green Bay Packers at Levi’s Stadium on January 19, 2020 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images) /

Week 13 – San Francisco 49ers (Away)

This game against the San Francisco 49ers marks the first of three primetime games over the next four weeks. The Bills will be traveling West to take on the 49ers on Monday Night Football.

Similar to the first primetime game, the Bills face an uphill climb as they will be playing the other team in this past Super Bowl and in addition will have to play this game on the road. The positive is that the team will have an extra day to prepare with this game being on Monday night.

Looking at the two teams, this is a game that will be won in the trenches as the 49ers have one of the best defensive lines in the game today. Meanwhile, the Bills defensive front will need to get pressure on Jimmy Garopollo to disrupt the passing attack and get penetration to slow down the second best rushing attack a season ago.

This is a game that doesn’t look to be in the Bills favor and they will be leaving with a loss.

Prediction: Loss (8-4)