Buffalo Bills @ New York Jets: Three Keys to the Game

ORCHARD PARK, NY - OCTOBER 29: Andre Holmes #18 of the Buffalo Bills and Eric Wood #70 of the Buffalo Bills hug after Holmes scored a touchdown during the second quarter of an NFL game on October 29, 2017 at New Era Field in Orchard Park, New York. (Photo by Tom Szczerbowski/Getty Images)
ORCHARD PARK, NY - OCTOBER 29: Andre Holmes #18 of the Buffalo Bills and Eric Wood #70 of the Buffalo Bills hug after Holmes scored a touchdown during the second quarter of an NFL game on October 29, 2017 at New Era Field in Orchard Park, New York. (Photo by Tom Szczerbowski/Getty Images) /
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ORCHARD PARK, NY – OCTOBER 29: LeSean McCoy #25 of the Buffalo Bills runs the ball during the third quarter of an NFL game against the Oakland Raiders on October 29, 2017 at New Era Field in Orchard Park, New York. (Photo by Brett Carlsen/Getty Images)
ORCHARD PARK, NY – OCTOBER 29: LeSean McCoy #25 of the Buffalo Bills runs the ball during the third quarter of an NFL game against the Oakland Raiders on October 29, 2017 at New Era Field in Orchard Park, New York. (Photo by Brett Carlsen/Getty Images) /

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The season opener was LeSean McCoy’s best week of the season. Until this past Sunday against the Oakland Raiders.

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With the offensive line clicking as of late and McCoy running in high gear these past two weeks, the Bills will likely rely on him again.

Muhammad Wilkerson questionable for Thursday night, so the already shaky Jets run defense could take a significant hit. New York allows 128.3 yards per game this season and Wilkerson sports a 73.3 run defense grade on Pro Football Focus.

This should be an area Buffalo attacks early and often.