San Francisco 49ers head into Week 13 vs. Bills in major injury trouble

Week 13 is here for the NFL and the Sunday games will close out with a potentially snowy game in Western New York between the Buffalo Bills and San Francisco 49ers. At the beginning of this season, this could have been pinned as a fantastic matchup to see but now it looks like the Bills could send the 49ers home with a huge loss.

While the Bills are coming into this game relatively healthy, the 49ers can’t say the same. Last Sunday, the 49ers traveled up to Green Bay and were blown out by the Packers, 38-10. Part of the reason why is because they didn’t have a lot of their starters, including quarterback brock Purdy, All-Pro edge rusher Nick Bosa, and All-Pro left tackle Trent Williams.

Brock Purdy should be ready to go, according to Matt Barrows per Kyle Shanahan. However, San Francisco will be coming to Buffalo heavily beaten up without a lot of valuable players.

According to Matt Barrows, the 49ers will be taking on the Bills without Nick Bosa, Trent Williams, CB Deommodore Lenoir, OL Aaron Banks, and DT Jordan Eliott.

In addition to those five, Nick Wagoner then reported that linebacker Dre Greenlaw, who was activated for his 21-day window practice period will not be playing in Buffalo as well.

49ers are in massive injury trouble for Week 13

This is starting to lean more towards a trap game for the Bills. You would think that San Francisco has no chance against a Bills team that is red hot. However, Bills fans cannot forget about players like Christian McCaffrey, Deebo Samuel, Fred Warner, and former Bill Leonard Floyd.

The 49ers still have a lot of talent, but losing the left side of the offensive line in front of Purdy who is still dealing with some shoulder soreness is not great news for them. The Bills need to take advantage of the mismatch that the 49ers have to go up against and send them back to California with their third consecutive loss.

As for the Bills, the only true game-time decision is wide receiver Keon Coleman who was limited throughout practice this entire week. However, he did not miss a practice so there is hope. As far as linebacker Matt Milano, there is a great chance that he will be able to play some football for the first since Week 5 of last season.

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