James Cook will have 100-plus rushing yards
We've talked about how good the Chiefs defense is this season. Their pass defense is ranked sixth in the league, allowing only 183 yards per game through the air. Their run defense is susceptible where they allow 114.7 yards per game, which ranks 19th in the league. Right behind them is the Bills allowing 116.7 per game; however, the Chiefs will be without their starting back, Isiah Pacheco.
The Bills have an opportunity here to attack the Chiefs' defense with their running game and in the last two games with Joe Brady calling the plays, the Bills have totaled 303 rushing yards. In addition, this would help negate some of the Chiefs' pass rush too. I see Brady calling Cook's number in this game and he'll pile up over 100 yards rushing.