Indianapolis Colts (Home Game)
Among all the potential opponents, the one that would give the best chance for the Buffalo Bills to win and advance would be the Indianapolis Colts. Similar to the Texans, they have a first year head coach in Shane Steichen and he has done a good job getting the Colts to this point.
He has been able to do it without Anthony Richardson, a first round quarterback who played great early in the season. However, he suffered a season ending injury and the team has turned to Gardner Minshew.
While Minshew has played well, he isn't the matchup nightmare that Richardson is or has the upside that Stroud does. The Colts do have Jonathan Taylor, who is one of the best running backs in the NFL, but it would be tough for the Colts to keep up with the Buffalo Bills offense. This is a game where Josh Allen should be able to find success against the cornerbacks.
If the Buffalo Bills are to make the playoffs, there is no necessarily easy matchups but the Colts game would probably be the best for the first round of the playoffs.