Honorable Mention: Kansas City Chiefs (Home)
Here we go again.
If the Bills hadn't played the Chiefs seven times over the past four seasons, including the playoffs, this matchup likely would have been higher on the list.
The Chiefs have eliminated the Bills from the playoffs in three of the past four seasons, so any regular season meeting between these two teams feels less important for the Bills until they finally beat Patrick Mahomes, Andy Reid, and Travis Kelce in January.
With the potential that this game is played in primetime, it deserves a spot on this list, but for the Bills to make any significance out of beating the Chiefs, it will have to be done outside of the regular season. The Bills winning each of the past three regular season meetings proves that this matchup is somewhat meaningless.
But here's to another shootout between two of the best quarterbacks in football.