Week 12: Buffalo Bills vs Philadelphia Eagles (Road)
This one will be tough and would be even if the Bills were healthy and playing well. The Eagles are as good as anyone in the league and might play themselves into representing the NFC in the Super Bowl again. Philadelphia is ranked fifth in the league in total offense; however, their defense hasn't been as good as it was last season, ranking 14th.
If the Bills can get their offense scoring points again, this game could be a lot closer than people probably think. As big of a matchup as this is, I don't think the season is dependent on winning this game, but it would be huge in terms of standings and confidence, but I think Buffalo will lose this one. Eagles win, 24 - 20