Detroit Lions
Another potential Super Bowl preview would be between the Buffalo Bills and Detroit Lions, as the Bills are scheduled to travel to Detroit for a regular season matchup. Similar to the 49ers, the Lions should be considered one of the favorites in the NFC and are coming off a season where they reached the Conference Championship Game.
The Lions last season would go 12-5 as Dan Campbell has helped turn their franchise around. Similar to the 49ers, the Lions have a number of stars on their team that would make sense for the NFL to highlight in prime time like Jahmyr Gibbs, Amon-Ra St. Brown, Sam LaPorta, and Aidan Hutchinson.
The fact that this game is going to be played inside of a dome certainly helps the chances of this being a high-scoring matchup as the Bills offense and Lions offense tries to outpace the other. This could a fun game and might even be one of the first prime time matchups of the season.