Predicting every prime time game for Buffalo Bills this 2024 season

The Buffalo Bills have had plenty of prime time matchups recently and this year should be no different. These are five matchups that could be great TV and the NFL will want to highlight in a prime time spot.
Buffalo Bills v New York Jets
Buffalo Bills v New York Jets / Al Pereira/GettyImages
3 of 5

San Francisco 49ers

The Buffalo Bills will be playing both teams from the Super Bowl last season after the Chiefs beat the San Francisco 49ers by a final score of 25-22 in overtime. The 49ers have emerged as one of the top teams in the NFC and this will be one of the top games played in Highmark Stadium this upcoming season.

Among all the teams in the NFL, the 49ers are probably one of the more balanced teams in the league. On the offensive side of the ball, they have Brandon Aiyuk and Deebo Samuel at wide receiver, with George Kittle at tight end, Christian McCaffrey at running back and the group is being led by Brock Purdy.

As good as the offense is, the defense might be even better with a great front seven with Nick Bosa, Dre Greenlaw, Fred Warner and former Buffalo Bills pass rusher Leonard Floyd. This matchup certainly has a chance to be a Super Bowl preview with these two teams and will be one of the top games this upcoming season.