2. Eric Wood - Center - 2009
Eric Wood will forever be a fan favorite and perhaps putting him as number two on this list is a little biased, but he was a bigger part and more vital to the Bills than the previously mentioned Thomas Smith. Also, in case you are wondering, I was following this team when Smith was playing, so it's not like I never watched him play either. Wood played ten seasons with the Bills, spanning his entire career, and was a starter on the Bills line from day one. He started every game he played throughout his career, totaling 120 games. Wood was voted to one Pro Bowl in 2015.
That 2009 draft wasn't known as a deep draft; however, one player of note that the Bills could have drafted (he was later traded to Buffalo) was running back LeSean McCoy, taken by the Philadelphia Eagles in the second round and 53rd overall. The Bills had three picks available to them before the Eagles picked at 53, which the Bills used to select Wood, safety Jairus Byrd, and another offensive lineman Andy Levitre, all three of these players went on to solid careers but imagine what could have been if the Bills would have chosen McCoy instead of Byrd. A rushing attack with McCoy in the backfield and Wood and Levitre leading the way could have been a formidable attack.