Buffalo has to get to Zach Wilson and get the sacks.
Buffalo is second in the league with 33 sacks on the year. In the first game between these two teams, the Bills recorded three sacks but had 12 total pressures. On many of those pressures, Zach Wilson was able to escape the pressure and avoid the sack. Buffalo could have racked up a lot more sacks in that game and will need to today.
The pressures also didn't lead to many turnovers, resulting in only one. This is an area where Wilson has done a decent job, throwing only six interceptions this season. He also has a couple of lost fumbles but if the Bills front can get after Wilson and force him into a few mistakes, it'll help give the Bills good field position and put them in favorable situations. Maybe they can even help out with a defensive touchdown. I think it'll only take 20+ to win this game and if the Bills defense can contribute a third of that, it would help tremendously.
Buffalo's offensive line has to play better than the previous matchup
Buffalo managed 97 yards rushing on 22 carries in the last meeting. They put up a solid 4.4 yards per carry average. The problem was the pass protection, as they struggled to protect Allen, sacking him five times and pressuring him 12 times. The pressures were a big part of what led to the four turnovers too.
According to PFF, the Bills offensive line ranks tenth in the NFL, a far cry from where they were a season ago. Hopefully, after ten games together, they do a better job of protecting Allen this time around. PFF issued grades over 70 in pass blocking for four of the Bills' five starting offensive linemen. Only O'Cyrus Torrence comes in under 70 on the season but he's still only allowed one sack this season. Protecting Allen will be key this time around.