James Cook
Over the last five games, the Chiefs are 2-3 and one common theme in their three losses has been the opposing team being able to run the ball effectively. In Week 8, the Broncos would run the ball 40 times and pick up 153 rushing yards.
Against the Eagles in Week 10, they would have 27 rush attempts and 114 rushing yards with three rushing touchdowns. Last week against the Packers, they would run the ball 25 times for 129 rushing yards.
The Bills are going to utilize all three running backs with James Cook, Latavius Murray, and Ty Johnson but Cook is the one player who can really be a difference maker for this offense. He has had three straight games with 100 or more yards from scrimmage and has had double digit carries each week.
If Joe Brady can get James Cook involved early, it will give the offense their best chance to put some points up against this defense.