During Joe Brady's time with the Carolina Panthers, he had one of the best running backs in the NFL in Christian McCaffrey. Unfortunately, McCaffrey was dealing with injuries and played only 10 games in the time Brady was offensive coordinator.
However, when he did play he was heavily involved and averaged close to 20 rushing attempts per game and around five receptions per game.
While James Cook may not be as elite as Christian McCaffrey he has a very similar skill set and was underutilized with Ken Dorsey calling plays, particularly as a receiver. Cook began the year with back to back games with four receptions in each game. However, in the past six games, he has had four receptions only once.
The Bills are going to need to establish a run game but they can also keep defenses honest by using James Cook as a receiver out of the backfield. If they can get him into space, he can pick up chunks of yards very quickly.