3.) Breece Hall
Not only can Cook do some damage, but the second-year back in Breece Hall is looking to pick up where he left off last season before tearing his ACL. In seven games last season, Hall had 430 rushing yards and four touchdowns, while averaging 66 yards per game.
Historically, players coming off a major injury like an ACL typically do not flash right away the next season or two, but because of the presence of Cook, Hall does not need to make any big plays which means he can go out there with no pressure to pick up the running game.
Hall did not face the Bills last season so this will be his first game against this defense. If Cook and Hall end up in a rotation, they will both be fresh against an exhausted Bills defense. Sean McDermott will need to account for two backs who can run the ball inside and outside the tackles.