5 bold predictions for Buffalo Bills vs. Jacksonville Jaguars in Week 5

5.) James Cook rushes for over 100+ yards

The run attack in Buffalo has been established since Week 2, led by second year back James Cook and the rest of the running back committee in Latavius Murray and Damien Harris, both of whom have been great red zone backs this season.

Cook has not only been a weapon in between the two 20-yard lines but also has been an extra weapon on the outside for Josh Allen. However, Cook has only had over 100 rushing yards once in his career, which happened in Week 2 against the Raiders with 123 rushing yards. 

Jacksonville has given up over 100 rushing yards in two of their four games this season, and with the Bills’ offensive line playing exceptional through three weeks, there is reason to believe that Cook could once again be a key factor in helping the Bills get the win in London.

Buffalo has dominated the time of possession in their wins, and part of the reason as to why they have is because of the running attack. Cook should be able to reach over 100 rushing yards against this top 12 defense in Jacksonville.