Buffalo Bills vs. Cleveland Browns: Final Week 16 score prediction

Buffalo Bills v New England Patriots - NFL 2025
Buffalo Bills v New England Patriots - NFL 2025 | Sarah Stier/GettyImages

In just over 24 hours, the Buffalo Bills will take the field against the Cleveland Browns in what should look like an easy game for the Bills, but we all know that anything can happen. Upsets occur all the time and the only thing the Browns are playing for right now is the offseason. As for Buffalo, they are still in the AFC East race with the Patriots.

These kinds of games are a trap for the better team. Buffalo has a lot more to lose than Cleveland so all the pressure is on Buffalo. For the past two weeks, the Bills have had to make a comeback in order to win which is thrilling, but it’s not sustainable. Taking on a team like the Browns means that the Bills should be able to handle them right out of the gate.

Kevin Stefanski could very well be coaching for his job and Shedeur Sanders is looking to show that the Browns don’t need to draft a quarterback next year despite having two first round picks. As for Buffalo, they are looking to get the best playoff seeding possible whether it’s them winning the AFC East for a sixth straight year, or having the best possible wild card spot.

Will Buffalo advance to 11-4 in Week 16 vs. Cleveland?

The Bills are winners of three straight while Cleveland is losers of three straight. Buffalo has the better overall roster and a little bit of better health with the roster. Despite Cleveland having the home field advantage, the Bills have shown that they can play well on the road and that should be no different this time around.

As long as the Bills don’t get off to a slow start like they have recently, there should be no worry for fans about leaving Cleveland with the win. In addition, if the Bills do defeat the Browns, they will have swept the entire AFC North this season.

Week 16 score prediction: Bills def. Browns, 34-17

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