Final 2022 regular season win-loss predictions for the Buffalo Bills

Week 2: Tennessee Titans at Buffalo Bills

The Tennessee Titans were one of the best teams in the AFC and even had the top seed in the playoffs. However, a lackluster performance against the Bengals ended a promising season on a down note.

During the offseason, the Titans made some notable changes on the offensive side of the ball by trading A.J. Brown to the Eagles and adding Robert Woods and rookie Treylon Burks. However, the offense is still going to run through Derrick Henry and slowing down the All-Pro is going to be the key to victory for the Buffalo Bills.

The Titans also will be entering this game without one of their top defensive players in Harold Landry. He suffered a torn ACL during practice and will now miss the remainder of the season.

Similar to the advantage the Rams had in front of their home crowd in Week 1, Buffalo should get that same advantage in a Monday night showdown with the Titans. This should be enough to help the Bills get their first win of the season.

Prediction: Win (1-1)