Final 2022 regular season win-loss predictions for the Buffalo Bills

The 2022 season is less than a week away for the Buffalo Bills. Training camp is over, preseason is complete and the 53-man roster is set. The focus now is on the Los Angeles Rams and starting the season off with a win.

When the schedule was released in May, I put together game-by-game predictions and had the Bills finishing 15-2. However, a lot has changed during these past few months and it is time to revisit the predictions and make my final win-loss prediction for the Buffalo Bills in 2022.

Predictions for every game on the Buffalo Bills 2022 schedule

Week 1: Buffalo Bills at Los Angeles Rams

The Buffalo Bills open the season in a high-profile game as they will take on the Los Angeles Rams in the first game of the entire 2022 season. This is a big game for the Rams and emotions will be running high as they will be raising their Super Bowl banner from their win over the Cincinnati Bengals last season.

The Rams have lost some key players from last year’s team like Von Miller, Andrew Whitworth, and Odell Beckham Jr. However, they have made notable additions as well like Allen Robinson and Bobby Wagner.

This has the potential to be a very close game between two of the best teams in the NFL and the edge slightly goes to the home team in this one.

Prediction: Loss (0-1)