Buffalo Bills 2022 schedule: Game-by-game predictions for every game

Week 2: Tennessee Titans at Buffalo Bills

The Buffalo Bills get an extended break with the Rams game being played on Thursday night and their next game isn’t until the following Monday. The Bills will return home to face the Tennessee Titans on Monday Night Football in the first game of a doubleheader on that night.

The Titans are an interesting team as they were the top seed in the conference last year but did trade away their star wide receiver this offseason by sending A.J. Brown to the Philadelphia Eagles. However, the Titans seemingly tried to replace him by drafting Treylon Burks in the first round and should have arguably the best running back in the NFL on the field in Derrick Henry.

Last year, the Bills lost a nailbiter to the Titans last year but with this season the matchup being a home game, that should be enough to swing the result in Buffalo’s favor.

Prediction: Win (1-1)