Buffalo Bills 2022 schedule: Game-by-game predictions for every game

The 2022 schedule has officially been released for the Buffalo Bills and there is plenty of marquee matchups for this upcoming season. The Bills will open the season against the Los Angeles Rams on Thursday Night Football in the very first game of the season.

They will have four more prime-time games over the season as well as a Thanksgiving matchup with the Detroit Lions. Now that the Buffalo Bills know what the 18 weeks will look like for them during the regular season, let’s make predictions for each game and see what their record may be for this upcoming season.

Week 1: Buffalo Bills at Los Angeles Rams

The Buffalo Bills get to open the season on the road, in front of a national audience as they face the defending Super Bowl champion Los Angeles Rams. This is a big game for the Rams as it will be their first game since their Super Bowl win and there will be plenty of celebrating before the kickoff.

On the field, this should be a great game between two of the top teams in the NFL. It is another opportunity for Josh Allen to put on a show and will also be a chance for Von Miller to play against his former team.

Von Miller should be a part of a key matchup in this game as the Rams will have a new left tackle with Andrew Whitworth retiring. However, the defending Super Bowl champions have won this game four straight years and that streak unfortunately continues here and the Bills start the season with a loss.

Prediction: Loss (0-1)