Turnover Battle
The key to this matchup, and what could ultimately decide the winner, is who wins the turnover battle between the Buffalo Bills and Indianapolis Colts. Right now, the Bills are first in the NFL in turnover differential at +14 with 24 forced turnovers (15 interceptions, 9 fumbles) and only 10 giveaways (6 interceptions, 4 fumbles).
However, the Colts are right behind them at second overall in the league with a turnover differential at +11 with 21 forced turnovers (10 interceptions, 11 fumbles) and only 10 giveaways (4 interceptions, 6 fumbles).
One of the reasons both teams are leading the NFL is that both quarterbacks have done a good job protecting the football for most of the season with Josh Allen having six interceptions while Carson Wentz only has three.
This looks like it will be another close game between two good teams and it could come down to the team that turns the ball over the least.