Jerry Hughes
Another point of emphasis for this coaching staff has to be getting pressure on quarterback Patrick Mahomes. While the Bills do have a number of new pass rushers like Greg Rousseau, Boogie Basham, and Efe Obada the defense should be looking to veteran Jerry Hughes to set the tone.
Hughes has been with the Buffalo Bills the longest of any player currently on the roster. He is a leader for this team and with a number of young defensive ends, they will likely look to him and Mario Addison as the veterans of the group.
This season, Hughes has gotten off to a slow start with only four total tackles and no sacks or QB hits. However, he has shown at times throughout the past few years that he can still make those game-changing plays. This would be a great time for Jerry Hughes to have one of those games in this primetime showdown.