Bills vs Chiefs Odds and Prediction for Week 5 NFL Game

Buffalo Bills quarterback celebrates his 1-yard touch down run in a 24-9 win over the Redskins.Jg 110319 Bills 15
Buffalo Bills quarterback celebrates his 1-yard touch down run in a 24-9 win over the Redskins.Jg 110319 Bills 15 /
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The Buffalo Bills are clicking on all cylinders heading into their Sunday Night Football clash with the Kansas City Chiefs in Week 5. Buffalo has responded to its season-opening loss with three straight wins by 20-plus points, including a 40-0 shellacking of the Houston Texans on Sunday.

Now the Bills enter this week with momentum on their side and revenge on their minds. The Chiefs crushed Buffalo’s Super Bowl dreams in last year’s AFC Championship Game, but KC doesn’t look like the same squad to start the 2021 campaign. This is the perfect opportunity for some payback.

Bills vs Chiefs Odds Week 5

The odds on WynnBet have Buffalo as a 3-point underdog heading into this matchup. They’re slight +125 moneyline underdogs (compared to -145 favorites for the Chiefs) to get the win in a game with a massive 57.0 over/under.

Bills vs Chiefs Prediction Week 5

Defense will be the story in this showdown between two top offenses.

The Josh Allen-led Bills are in position to thrash a Chiefs defense with obvious holes. Kansas City is giving up the second-most points per game (31.3) in the league, which should have the NFL’s second-highest scoring offense (33.5 PPG) licking its chops. Buffalo’s defense, meanwhile, has been equally as strong. This unit is the league’s stingiest in opponent PPG at just 11.0.

This contest should be tight given the offensive talent lining up, but it’s way more likely the Chiefs’ defense costs them the game. This unit allowed both the Baltimore Ravens and Los Angeles Chargers to put up double digits in the fourth quarter of their two losses this year.

Patrick Mahomes has to be on top of his game. His defensive counterparts have already proven they can’t be relied on (against lesser offenses, too).

Buffalo pulls off the road upset and wins, 31-28.

Think the Bills or Chiefs will score a touchdown in this game? Bet $1 and win $100 if either score one TD in the game. Claim your offer at WynnBET now.