Buffalo Bills Game Sunday: Bills vs Steelers odds and prediction for NFL Week 1

Josh Allen, Buffalo Bills (Photo by Kirk Irwin/Getty Images)
Josh Allen, Buffalo Bills (Photo by Kirk Irwin/Getty Images) /

The Buffalo Bills open the 2021 season at home, facing the visiting Pittsburgh Steelers. This will be the first matchup between Buffalo and Pittsburgh since December 13, 2020; a 26-13 Bills victory.

The Bills are coming off a 13-3 2020 season, and expectations remain high in 2021, as Josh Allen looks to build on his growing presence in the NFL’s fraternity of quarterbacks. Coming off a Pro-Bowl selection, Allen has Buffalo fans thinking about the Super Bowl.

Stream the Bills with fuboTV. Local channels available in most market, Cloud DVR, no cancellation fees. Start a 7-day free trial today and watch Week One for free.

The Steelers went 12-4 last season, including an 11-0 stretch to start the season, but struggled down the stretch. Ben Roethlisberger returns for his 18th season at quarterback, and will have a new member in the backfield in 24th overall draft pick, Najee Harris, at running back.

Pittsburgh Steelers vs. Buffalo Bills Odds Week 1

The Week 1 betting odds on WynnBET have the Bills as -6.5 point favorites at home. They have -290 odds on the money line, while Pittsburgh is the underdog at +230. The total for the game is set at an Over/Under of 44.5 points.

Pittsburgh Steelers vs. Buffalo Bills Prediction Week 1

The Bills are at home against the third-ranked scoring defense from 2020, and while Pittsburgh may have lost a few pieces, the defense should still keep points off the board. Allen may have his hands full with the Steelers’ defense after they gave up just 194.4 passing yards per game.

The Buffalo running game, which has some questions surrounding it as we approach Week 1, should be expected to take a fairly large role. Even if Allen has to do some of the running himself.

This has the potential to be a lower-scoring game. With offenses looking to jell, and defenses looking to expose their opponent offenses, we’re predicting that Pittsburgh will hang within the +6.5 point spread; a 21-17 Bills victory.

Make your pick now on WynnBET.