The Best Buffalo Bills players to wear 21-25

22 Nov 1998: Running back Antowain Smith #23 of the Buffalo Bills in action during the game against the Indianapolis Colts at the Bills Stadium in Orchard Park, New York. The Bills defeated the Colts 34-11. Mandatory Credit: Rick Stewart /Allsport
22 Nov 1998: Running back Antowain Smith #23 of the Buffalo Bills in action during the game against the Indianapolis Colts at the Bills Stadium in Orchard Park, New York. The Bills defeated the Colts 34-11. Mandatory Credit: Rick Stewart /Allsport /
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Buffalo Bills runningback Terrence McGee (24) during the game against the New England Patriots at Ralph Wilson Stadium in Orchard Park, New York on December 11, 2005. The Patriots defeated the Bills 35-7. (Photo by Robert Skeoch/NFLPhotoLibrary) /

The Best Buffalo Bills players to wear 21-25 are dominated by running backs.

Our fifth installment of the best Buffalo Bills players by jersey number continues with numbers 21-25. We nearly had a clean sweep of numbers by running backs, and I guess when given the number territory it’s expected. Some of these were so close to each other, just a few hundred yards or small differences in their stats made the difference in who got chosen.

To be clear, this done using Pro Football Reference’s uniform history chart for the Bills. If there’s a player that I didn’t cover or wasn’t on that list, then please reach out to PFR to correct that. I’m working with what’s given on the website. I have individually gone and clicked on every single player to make sure these are the cream of the crop.

Without any more hesitation, let’s hand it off and let the running backs take us the distance, going through the best Buffalo Bills by uniform numbers 21-25.