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Buffalo Bills: Game-by-game predictions for the 2021 season

By Brandon Croce

ORCHARD PARK, NEW YORK - DECEMBER 13: Buffalo Bills offense lines up against the Pittsburgh Steelers defense during the fourth quarter at Bills Stadium on December 13, 2020 in Orchard Park, New York. (Photo by Bryan Bennett/Getty Images)
ORCHARD PARK, NEW YORK - DECEMBER 13: Buffalo Bills offense lines up against the Pittsburgh Steelers defense during the fourth quarter at Bills Stadium on December 13, 2020 in Orchard Park, New York. (Photo by Bryan Bennett/Getty Images) /
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CHARLOTTE, NORTH CAROLINA – AUGUST 16: Ed Oliver #91 of the Buffalo Bills reacts against the Carolina Panthers during the third quarter of their preseason game at Bank of America Stadium on August 16, 2019 in Charlotte, North Carolina. (Photo by Grant Halverson/Getty Images) /

Week 15: Carolina Panthers at Buffalo Bills

The connection between the Carolina Panthers and Buffalo Bills is well documented but this is a very different team from when Sean McDermott and Brandon Beane were a part of the organization.

The Panthers are now led by head coach Matt Rhule and offensive coordinator Joe Brady but will have someone under center the Bills are plenty familiar with in Sam Darnold. He was formerly with the Jets but they traded him to the Panthers before the NFL Draft.

The Carolina Panthers are a team on the rise but are still young and developing. The Buffalo Bills lean on their experience here and come away with a win.

Predictions: Win (11-3)

Week 16: Buffalo Bills at New England Patriots

The Buffalo Bills head out for the final road game of the season as they face the New England Patriots for the second time in a four week span. Last year, the Bills were able to come away with a win in Gillette Stadium and sweep the New England Patriots.

However, this is not very common and this year the Bills come up short as Bill Belichick is able to make some changes to his gameplan with the first game so close to this one. The Patriots stop the sweep and come away with a win over the Buffalo Bills.

Prediction: Loss (11-4)

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