Buffalo Bills: Game-by-game predictions for the 2021 season

ORCHARD PARK, NEW YORK - DECEMBER 13: Buffalo Bills offense lines up against the Pittsburgh Steelers defense during the fourth quarter at Bills Stadium on December 13, 2020 in Orchard Park, New York. (Photo by Bryan Bennett/Getty Images)
ORCHARD PARK, NEW YORK - DECEMBER 13: Buffalo Bills offense lines up against the Pittsburgh Steelers defense during the fourth quarter at Bills Stadium on December 13, 2020 in Orchard Park, New York. (Photo by Bryan Bennett/Getty Images) /
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Dec 28, 2020; Foxborough, Massachusetts, USA; Buffalo Bills wide receiver Stefon Diggs (14) runs the ball for a touchdown against New England Patriots cornerback J.C. Jackson (27) and defensive back Jonathan Jones (31) in the half quarter at Gillette Stadium. Mandatory Credit: David Butler II-USA TODAY Sports /

Week 13: New England Patriots at Buffalo Bills (Monday Night Football)

The Buffalo Bills return home and with a little extended rest before facing the New England Patriots on Monday Night Football. This is the Bills’ only home primetime game and could be playing their third rookie quarterback of the season with Mac Jones potential under center.

The Patriots are a team that invested a lot in free agency to improve this team and they certainly should be better than they were a season ago. However, the Bills at this point of the season are going to be focused on securing the AFC East division title and this will be a critical win to achieving that.

A primetime game in front of the home crowd with those stakes, the Buffalo Bills get the job done and come away with a win.

Prediction: Win (10-2)

Week 14: Buffalo Bills at Tampa Bay Buccaneers

After playing the New England Patriots, the Bills head south to face the former face of the Patriots’ franchise in Tom Brady. This past season he led the Bucs to a Super Bowl title and the Bucs were able to bring back every single starter from that team.

This is a very good Bucs team that should only get better and with this game on the road, the Buffalo Bills fall short.

Prediction: Loss (10-3)