Buffalo Bills: Ranking the toughest games remaining on the schedule
Number 4: San Francisco 49ers
At the start of the season, this game looked much tougher. The 49ers had a dominant defense and were coming off a run that ended at the Super Bowl, a game which they lost to the Kansas City Chiefs.
However, they have lost a number of key pieces this season due to injuries like Richard Sherman, Nick Bosa, Solomon Thomas, Dee Ford, George Kittle, and Jimmy Garoppolo. There is a chance that some of these players, like Sherman, Ford, and Garoppolo, could be back for this game.
If the 49ers do get some of these players back and considering this will be a cross country trip for the Bills, it makes this game a little tougher. The question is what this team will look like by Week 13 but this is another game, as it stands now, that the Buffalo Bills should win.