Week 13 – San Francisco 49ers (Away)
This game against the San Francisco 49ers marks the first of three primetime games over the next four weeks. The Bills will be traveling West to take on the 49ers on Monday Night Football.
Similar to the first primetime game, the Bills face an uphill climb as they will be playing the other team in this past Super Bowl and in addition will have to play this game on the road. The positive is that the team will have an extra day to prepare with this game being on Monday night.
Looking at the two teams, this is a game that will be won in the trenches as the 49ers have one of the best defensive lines in the game today. Meanwhile, the Bills defensive front will need to get pressure on Jimmy Garopollo to disrupt the passing attack and get penetration to slow down the second best rushing attack a season ago.
This is a game that doesn’t look to be in the Bills favor and they will be leaving with a loss.
Prediction: Loss (8-4)