Week 10 – Arizona Cardinals (Away)
After a tough contest with the Seattle Seahawks, the Buffalo Bills will have to travel cross country to face the Arizona Cardinals. The Cardinals are an interesting team and one that is hard to get a read on how this upcoming season will go for them.
They are coming off a season they went 5-10-1 but their franchise quarterback Kyler Murray and head coach Kliff Kingsbury have a season now under their belt. They should be better prepared entering Year 2 and have two excellent wide receivers at their disposal now with DeAndre Hopkins joining Larry Fitzgerald.
Even with that said, the Bills are still the better team on paper and have a much stronger defense that should be able to neutralize the Cardinals offense. This is a game that may not be pretty, but the Bills should come away with a win here.
Prediction: Win (7-3)